Effects of puerarin on fatty superoxide in aged mice induced by D-galactose.
- Author:
Xiao-hong XU
1
Author Information
- Publication Type:Journal Article
- MeSH: Aging; blood; metabolism; Animals; Behavior, Animal; drug effects; Female; Galactose; Isoflavones; isolation & purification; pharmacology; Male; Malondialdehyde; metabolism; Mice; Plants, Medicinal; chemistry; Pueraria; chemistry; Superoxide Dismutase; metabolism
- From: China Journal of Chinese Materia Medica 2003;28(1):66-69
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of puerarin on fatty superoxide of aged mice induced by D-galactose.
METHODThe aged mice were induced by s.c. 0.12 g.kg-1 D-galactose for 6 weeks. Meanwhile, they were treated with three doses of puerarin once a day for 6 weeks. Then the spontaneous behavior was tested in the aged mice using open field at the next day after the last treatment. And the activity of SOD, the contents of MDA and lipofuscin in brain, liver, and serum were measured with Ultravioletray spectrometer and Fluorospectrophometer analysis system.
RESULTCompared with the D-galactose control group, puerarin of 50 mg.kg-1 and 100 mg.kg-1 puerarin significantly increased the spontaneous behavior, remarkably promoted the activity of SOD of brain, liver, and serum in the aged mice, and significantly decreased the contents of MDA and lipofuscin.
CONCLUSIONPuerarin can improve the activity of antioxidase of the modelling aged-mice induced by D-galactose.
