Studies on new trierpenoid constituents from the Rhizoma of Cimicifuga foetida.
- Author:
Xiao-hong ZHAO
1
;
Di-hua CHEN
;
Jian-yong SI
;
Rui-le PAN
;
Lian-gang SHEN
;
Duo CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Neoplasms; pathology; Cell Division; drug effects; Cell Line, Tumor; Cimicifuga; chemistry; Lanosterol; analogs & derivatives; chemistry; isolation & purification; pharmacology; Molecular Structure; Osteoblastoma; pathology; Plants, Medicinal; chemistry; Rats; Rhizome; chemistry; Triterpenes; chemistry; isolation & purification; pharmacology
- From: China Journal of Chinese Materia Medica 2003;28(2):135-138
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo find new active constituents from Rhizome of Cimicifuga foetida.
METHODVarious column chromatographic techniques were employed for isolation and purification. The structures were elucidated on the basis of spectral and chemical evidences.
RESULTFour triterpenoid compounds were isolated and identified as 7,8-didehydro-27-deoxyactein(1), 24-O-acetylshengmanol-3-O-beta-D-xyl (23R, 24R)[2], cimigenol(3), cimigenol-3-O-beta-D-xyl(4).
CONCLUSIONCompound 1 is a new compound, 2-4 were obtained from this medicinal material for the first time. The antiosteoporosis activity screening in vitro(by the method of SRB) indicates that Compounds 1, 2 and 4 can promote the proliferation for rat Osteoblastoma cell line (UMR106) at the concentration of 10(-9) kg.L-1.
