Effect of SS8, the active part of Spatholobus suberectus Dunn, on proliferation of hematopoietic progenitor cells in mice with bone marrow depression.
- Author:
Dong-xiao WANG
1
;
Meng-li CHEN
;
Jian-fen YIN
;
Ping LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Marrow Cells; radiation effects; Cell Division; drug effects; Drugs, Chinese Herbal; isolation & purification; pharmacology; Erythroid Precursor Cells; drug effects; radiation effects; Fabaceae; chemistry; Female; Hematopoietic Stem Cells; cytology; drug effects; radiation effects; Male; Mice; Plants, Medicinal; chemistry; Whole-Body Irradiation
- From: China Journal of Chinese Materia Medica 2003;28(2):152-155
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of SS8, a monomer extracted from Spatholobus suberectus Dunn used for invigorating the circulation of blood, on proliferation of hematopoietic progenitor cells in mice with bone marrow depression.
METHODThe method of semi-solid culture with methylcellulose of CFU-GM, CFU-E, BFU-E, CFU-Meg was adopted in bone marrow depressed mice which were treated with SS8 for a long time.
RESULTThe experimental data demonstrated that the numbers of CFU-GM, CFU-E, BFU-E, CFU-Meg in bone marrow depressed mice were raised distinctly under the control of SS8 as compared with those of contrast group. The effect of SS8 became stronger as time went on and the dosage rose.
CONCLUSIONSS8 can distinctly stimulate the proliferation of hematopoietec progenitor cells in mice with bone marrow depression in a time-and-dosagedependent manner.
