Effect of Astragalus membranaceus on baroreflex sensitivity in spontaneously hypertensive rats.
- Author:
Zhi-kui CHEN
1
;
Shen-jiang HU
;
Xia ZHEN
;
Guo-bing WANG
;
Jian SUN
;
Qiang XIA
;
Yue-liang SHENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antihypertensive Agents; isolation & purification; pharmacology; Astragalus membranaceus; chemistry; Baroreflex; drug effects; Blood Pressure; drug effects; Drugs, Chinese Herbal; isolation & purification; pharmacology; Hypertension; physiopathology; Male; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Inbred SHR
- From: China Journal of Chinese Materia Medica 2003;28(2):155-158
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the chronicity decompression effect of Astragalus Membranaceus(AM) and evaluate the effect on baroreflex sensitivity (BRS).
METHODNineteen spontaneously hypertensive rats(SHR) were randomly divided into four groups. The AM groups were intraperitoneally administered with AM parenteral solution 0.9 mL, 1.2 mL and 1.8 mL respectively and the control group was not given AM for eight weeks. Then the change of blood pressure was observed successivly. After eight weeks, BRS were also determined. At last, the difference of blood pressure and BRS among the groups were compared.
RESULTBlood pressure in the control group became higher and higher frome the third week to the eighth week, but the other SHR admistered with AM showed no changein blood pressure level. We also found that the BRS in AM group was higher than that in the control group(P < 0.01).
CONCLUSIONAM can promote the BRS in SHR.
