The effects of Erigeron breviscapus preparation on the imaging and neuronal metabolites at the early time points after reperfusion following the ischemic cerebral injury in rats.
- Author:
Wei-jing LIAO
1
;
Yun-huang YANG
;
Ming FAN
;
Wan-tong YANG
;
Li-yun LI
;
Mai-li LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Aspartic Acid; analogs & derivatives; metabolism; Asteraceae; chemistry; Brain; metabolism; pathology; Brain Ischemia; etiology; Choline; metabolism; Creatine; metabolism; Drugs, Chinese Herbal; isolation & purification; pharmacology; Infarction, Middle Cerebral Artery; complications; Injections; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; etiology; metabolism; pathology
- From: China Journal of Chinese Materia Medica 2003;28(2):163-166
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of Erigeron breviscapus preparation on the imaging and neuronal metabolites after reperfusion in the ischemic cerebral injury in rats.
METHODTwenty-three male Sprague Dawley rats with an average body weight of (165 +/- 15) g (mean +/- S) were used, and were randomly divided into two groups: group A rats (n = 11) underwent an operation of ischemic brain injury, group B rats (n = 12) underwent the same operation and received the treatment of Erigeron breviscapus preparation (1.5 mg.kg-1 weight, i.p.). The right middle cerebral artery occlusion (MCAO) of rats in both groups was induced by 5/0 nylon suture for 2 hours. The reperfusion was conducted for four hours and six hours respectively following MCAO. T2 weighted-imaging (T2WI) and 1H-magnetic resonance spectroscopy (1H-MRS) were performed, to study the changes of the imaging and the neuronal metabolites N-acetyl aspartate (NAA), creatine/phosphocreatine (Cr/PCr), choline (Cho) and lactose (Lac) in cerebrum following cerebral ischemia.
RESULTThe hyperintense signals in the right cerebrum in group B decreased compared with those in group A, the T2 values decreased, the level of NAA increased, the ratio of Cr/NAA and Cho/NAA decreased, and no lactose was observed. The brain surface vessels of rats in group B were in the state of dilation.
CONCLUSIONErigeron breviscapus preparation is beneficial to the reestablishment of the blood circulation in the ischemic brain, and to the improvement of the neuronal metabolism and survival.
