Studies on variation of danshensu content in accelerated stability tests.

Author: Sheng-jun MAO ¹ ; Shi-xiang HOU ; Chang-jiong TANG ; Xiao-dong HUANG
Author Information

1. Pharmaceutical Laboratory of Chinese Materia Medica, West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China.
Publication Type:Journal Article
MeSH: Chromatography, High Pressure Liquid; Drug Stability; Hydrolysis; Hydroxybenzoates; chemistry; Injections; Lactates; administration & dosage; analysis; chemistry; Temperature
From: China Journal of Chinese Materia Medica 2003;28(3):220-222
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo study the variation Laws of content of danshensu accelerated in control and in danshen injection in order to provide reference for stability investigation of danshensu.
METHODThe tests was carried out by classic isothermal method and the content of danshensu was determined by HPLC.
RESULTThe contents of danshensu in accelerated tests increase in control and decrease in danshen injection respectively.
CONCLUSIONThe component of phenic acidity would be hydrolyzed to become danshensu in the accelerated tests. Much attention should be paid to the unusual increase when studies of danshen preparations are carried out.