Studies on stability of chlorogenic acid in extract of Flos lonicerae.
- Author:
Gang CHEN
1
;
Shi-xiang HOU
;
Ping HU
;
Ning HE
;
Ya-ning ZHU
;
Lun CAO
Author Information
- Publication Type:Journal Article
- MeSH: Calcium Hydroxide; Chlorogenic Acid; chemistry; isolation & purification; Chromatography, High Pressure Liquid; methods; Drug Stability; Flowers; chemistry; Hydrogen-Ion Concentration; Hydrolysis; Lonicera; chemistry; Plants, Medicinal; chemistry; Sodium Hydroxide; Solutions; Technology, Pharmaceutical; methods
- From: China Journal of Chinese Materia Medica 2003;28(3):223-226
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the stability of chlorogenic acid in extract of flos lonicerae in different conditions.
METHODThe stability of chlorogenic acid in extract of flos lonicerae in phosptat buffe with different pH values, methanol, ethanol and different base solutions(Ca(OH)2 and NaOH) was investigated by the classical isothermal method.
RESULTThe experiments showed the chlorogenic acid in extract of flos lonicerae was more stable in acidic water than in basic water. It was stable in these organic solutions and base solution[Ca(OH)2].
CONCLUSIONIn different conditions, the stability of chlorogenic acid in extract of flos lonicerae was different. It provided a reference to the extraction and analysis of chlorogenic acid and production of chlorogenic acid preparation.
