Comparative study on antibacterial effects of huangqin-tang and its metabolites produced by intestinal flora.
- Author:
Mei-zhen YAN
1
;
Feng ZUO
;
Hong-yue SONG
;
Wen-hua YE
;
Zhong-ming ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Bacterial Agents; pharmacology; therapeutic use; Drugs, Chinese Herbal; pharmacology; therapeutic use; Escherichia coli Infections; drug therapy; Feces; microbiology; Intestines; microbiology; Male; Mice; Phytotherapy; Plants, Medicinal; chemistry; Proteus; drug effects; Salmonella; drug effects; Shigella dysenteriae; drug effects; Staphylococcal Infections; drug therapy
- From: China Journal of Chinese Materia Medica 2003;28(3):243-246
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the antibacterial effects of Huangqin-Tang with its metabolites produced by intestinal flora.
METHODThe antibacterial tests in vitro and in vivo were performed by agar dilution method and lethal protection of animal respectively.
RESULTHuangqin-Tang and its metabolites had antibacterial action on bacteria in vitro, however the antibacterial activity of metabolites of Huangqin-Tang on Salmomella, Dysentery bacillus and Proteus in vitro was stronger than Huangqin-Tang. The metabolites of Huangqin-Tang had protective effect on the animals infected by Staphylococcus aureus and Escherichia coli respectively from death, but Huangqin-Tang had no lethal protection action.
CONCLUSIONThe antibacterial effects of metabolites of Huangqin-Tang in vitro and in vivo are stronger than that of Huangqin-Tang, which shows that intestinal flora play a very important role in antibacterial effects of Huangqin-Tang.
