Effects of tanguticum maxim polysaccharide on ulcerative colitis induced by TNBS in rats.
- Author:
Li LIU
1
;
Qi-bing MEI
;
Si-yuan ZHOU
;
Feng-hua HAN
;
Yin LONG
;
Jia-yun LIU
;
Chen LI
;
Jing-ru MENG
;
Zhi-peng WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Inflammatory Agents, Non-Steroidal; therapeutic use; Colitis, Ulcerative; chemically induced; drug therapy; Colon; enzymology; pathology; Male; Phytotherapy; Plants, Medicinal; chemistry; Polysaccharides; isolation & purification; therapeutic use; Rats; Rats, Sprague-Dawley; Rheum; chemistry; Trinitrobenzenesulfonic Acid
- From: China Journal of Chinese Materia Medica 2003;28(3):246-249
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effects of Tanguticum Maxim polysaccharide (TMP-1) on TNBS-induced colitis in rats.
METHODRats with TNBS/ethanol-induced colitis were used and treated with TMP-1 and dexamethasone (DX). Seventy-two rats, including animals with TNBS-induced colitis, were treated with saline, TMP-1 (100, 200, 400 mg.kg-1) and DX. White blood cells were counted on the fifth day and the rats were killed by ether on the sixth day. SOD activity in serum, MPO and SOD activity of colonic tissue were measured.
RESULTThe remarkable effects of TMP-1 at dosage of 200, 400 mg.kg-1 on TNBS-induced colitis were observed. The ulcerative area was diminished and weight of colon was reduced. White blood cell population was reduced, SOD activity in serum and SOD activity of colon tissue were remarkably increased, and, MPO activity of colonic tissue was reduced.
CONCLUSIONTMP-1 has significant effects on TNBS-induced colitis in rats with lower side effects, which suggests the effective component of rhubarb on colitis perhaps is TMP. The mechanism of the actions of TMP may relate to its antiflammation, antioxidation and immunoloregulation.
