The effect of niaoduqing tablet on the diuresis in normal rats and the hemorheology in blood-stasis rats.
- Author:
Hong-zhu DENG
1
;
Wei XIAO
;
Yu-yao CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Viscosity; drug effects; Diuresis; drug effects; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; pharmacology; Female; Fibrinogen; metabolism; Hematocrit; Hemorheology; drug effects; Male; Medicine, Chinese Traditional; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley; Tablets
- From: China Journal of Chinese Materia Medica 2003;28(3):250-253
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of the Niaoduqing Tablet(NDT) on the diuresis in normal rats and the hemorheology in rats of blood stasis and compare it with the Niaoduqing Granule(NDG), so as to provide some laboratory data for the clinic application and innovation of the dosage forms.
METHODDiuretic effect of the NDT on experimental rats burthened with 1% Sodium deoxycholate was observed by using the metabolize cage examination. The changes of whole blood and plasma viscosity in the blood-stasis rat-model were measured with Viscometer-R80. Plasma was separated and fibrinogen measured by using the turbidimetric method.
RESULTEvery dose of NDT had the diuretic effect on experiment rats, but only the big and middle dose increasing the urine quantity in 6 hours had the significance. Each dose could reduce the viscosity of whole blood and the fibrinogen in the blood-stasis rat model, and had the superiority to NDG.
CONCLUSIONSNDT has the diuretic effect and can ameliorate the hemorheology in the blood-stasis rat model, which may delay the course of the chronic renal failure (CRF).
