The influence on hemodynamics of myocardial ischemic dogs and blood pressure of animals with shenfu injection.
- Author:
Fang-ju YANG
1
;
Zheng-rong WANG
;
Dai-ping LIN
;
Yi QU
;
Hua-hu YIN
;
Li-li SHI
;
Hui-ling GUO
;
Jing XIAO
;
Yue-qi WANG
;
Rong-tao LIU
Author Information
- Publication Type:Journal Article
- MeSH: Aconitum; chemistry; Alkaloids; isolation & purification; pharmacology; Animals; Blood Pressure; drug effects; Dogs; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacology; Ginsenosides; isolation & purification; pharmacology; Hemodynamics; drug effects; Hypertension; physiopathology; Injections; Male; Myocardial Ischemia; physiopathology; Panax; chemistry; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines; isolation & purification; pharmacology
- From: China Journal of Chinese Materia Medica 2003;28(3):259-262
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the influence of Shenfu injection on the hemodynamic indexes of myocardial ischemic dogs and blood pressure of dogs and rats.
METHODMyocardial ischemic model was made and hypotension in the dogs was induced with ligating left front descending limb coronary artery method, and secondary hypertension by narrowing nephridium artery of rats, Shenfu injection was administered with 5, 10 mL.kg-1 to the above dogs and rats separately to investigate the influence of it on the hemodynamic indexes of myocardial ischemic dogs and blood pressure of rats.
RESULT AND CONCLUSIONShenfu injection enhanced the capacity of myocardial work markedly; it augmented the myocardium contractility and cardiac output without raising the oxygen consume, and at the same time it returned normal the blood pressure in myocardial ischemic; but it had no effects on the normal blood pressure and secondary hypertension of rats.
