Advances in molecular mechanisms of tenascin-C in promoting tumor metastasis.
- Author:
Yunhong NONG
;
Lang BAI
;
Hong TANG
- Publication Type:Journal Article
- MeSH:
Cell Adhesion;
Humans;
Integrins;
Matrix Metalloproteinases;
Neoplasm Metastasis;
Neoplasms;
Neovascularization, Pathologic;
Signal Transduction;
Tenascin;
physiology;
Vascular Endothelial Growth Factor A
- From:
Journal of Biomedical Engineering
2015;32(1):240-244
- CountryChina
- Language:Chinese
-
Abstract:
Tenascin-C (TNC) is an extracellular matrix glycoprotein, which is usually highly expressed in embryonic tissues and tumor tissues, but is not expressed or just lowly expressed in mature tissues. TNC is involved in various complex signaling pathways during tumor metastasis, especially through modulating FAK, RhoA, Wnt and Notch pathways by interacting with syndecan-4, integrin α5β1, matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF). As a result, TNC affects epithelial mesenchymal transition, tumor cell adhesion, proliferation and angiogenesis, which eventually enhances the invasion and metastasis ability of many tumors. Further studies have demonstrated that TNC could be used as prognosis or metastasis marker of patients with malignant tumor.
