Synthesis of propenamides with anti-malarial activities and 3D-QSAR study.
- Author:
Mao-sheng CHENG
1
;
Dong YAN
;
Qian-li WANG
;
Li ZHANG
;
Jian-min SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Acrylamides; chemical synthesis; chemistry; pharmacology; Animals; Antimalarials; chemical synthesis; chemistry; pharmacology; Chloroquine; pharmacology; Drug Resistance; Molecular Conformation; Molecular Structure; Plasmodium; drug effects; Quantitative Structure-Activity Relationship
- From: Acta Pharmaceutica Sinica 2003;38(7):505-510
- CountryChina
- Language:English
-
Abstract:
AIMTo establish 3D QSAR model of propenamides with anti-malarial activities.
METHODSChemical synthesis combined with comparative molecular field analysis (CoMFA).
RESULTSGenerated QSAR models for activities of inhibiting chloroquine resistive malaria (W2) and chloroquine sensitive malaria (D6).
CONCLUSIONThe activity of anti-W2 depends mostly on steric interaction and the activity of anti-D6 depends on both steric and electrostatic interaction.
