Microbial transformation of sinenxan A, a rich constituent in callus cultures of Taxus.
- Author:
Ji-xun ZHAN
1
;
Jian-jiang ZHONG
;
Jun-gui DAI
;
Hong-zhu GUO
;
Wei-hua ZHU
;
Yuan-xing ZHANG
;
De-an GUO
Author Information
- Publication Type:Journal Article
- MeSH: Acetates; isolation & purification; metabolism; Biotransformation; Culture Techniques; Cunninghamella; metabolism; Diterpenes; isolation & purification; metabolism; Mucor; metabolism; Plants, Medicinal; chemistry; Proteus vulgaris; metabolism; Taxus; chemistry
- From: Acta Pharmaceutica Sinica 2003;38(7):555-558
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the microbial transformation of sinenxan A.
METHODSChoose two strains of Fungi (Mucor spinosus AS 3.3450 and Cunninghamella echinulata AS 3.3400) and a strain of bacterium (Proteus vulgaris AS 1.1208) to transform the substrate.
RESULTSThree products were obtained and identified as 10-deacetylsinenxan A1, 6 alpha-hydroxy-10-deacetylsinenxan A2 and 9 alpha-hydroxy-10-deacetylsinenxan A3 respectively.
CONCLUSIONSinenxan A is facile to be transformed by microorganisms, the 10-acetyl group of which is an active group.
