Pharmacokinetics of osthole in rabbits.
- Author:
Fang AN
1
;
Shu-hua WANG
;
Dan-shen ZHANG
;
Li ZHANG
;
Jin-xiu MU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Area Under Curve; Calcium Channel Blockers; blood; isolation & purification; pharmacokinetics; Chromatography, High Pressure Liquid; Cnidium; chemistry; Coumarins; blood; isolation & purification; pharmacokinetics; Fruit; chemistry; Male; Metabolic Clearance Rate; Plants, Medicinal; chemistry; Rabbits; Tissue Distribution
- From: Acta Pharmaceutica Sinica 2003;38(8):571-573
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the pharmacokinetics of osthole in rabbits and obtain the main pharmacokinetic parameters.
METHODSA simple high-performance liquid chromatography (HPLC) method was developed to study the pharmacokinetics of osthole in rabbits by joining an internal standard (paeonal). Methanol-water (80:20) was used as the mobile phase. According to the 3P87 pharmacokinetic program, the main parameters were calculated.
RESULTSThe osthole pharmacokinetics conforms to a two compartment open model after i.v. administration, T1/2 alpha = 5.81 min, T1/2 beta = 42.2 min, K21 = 0.036 0.min-1, K12 = 0.045 0.min-1, K10 = 0.054 0.min-1, AUC = 235 mg.min.L-1, CLs = 0.043 0 L.min-1.kg-1, Vc = 0.780 L.kg-1.
CONCLUSIONThe pharmacokinetics of osthole after i.v. administration showed a rapid distribution and elimination process in rabbits.
