Sandwiched osmotic pump tablet for controlled release of water-insoluble drug.
- Author:
Long-xiao LIU
1
;
Gilson KHANG
;
John Moon RHEE
;
Hai Bang LEE
Author Information
- Publication Type:Journal Article
- MeSH: Cellulose; analogs & derivatives; chemistry; Delayed-Action Preparations; Drug Carriers; Nifedipine; administration & dosage; Osmosis; Polyethylene Glycols; chemistry; Potassium Chloride; chemistry; Solubility; Tablets; Technology, Pharmaceutical; methods
- From: Acta Pharmaceutica Sinica 2003;38(8):620-623
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study sandwiched osmotic pump tablet for delivering water-insoluble drug for 24 hours.
METHODSSandwiched osmotic pump tablet was prepared using nifedipine as the model drug. The effects of various formulation variables and orifice size on drug release were studied. The mechanical properties of cellulose acetate membrane were also investigated.
RESULTSPolyethylene oxide of drug layer and potassium chloride of push layer showed marked positive effects on drug release. In the range of 0.50 mm to 1.40 mm, orifice size hardly affects drug release. Cellulose acetate membrane is strong enough to assure the integrity of osmotic pump tablet and could sustain an internal pressure ranging from 0.34 MPa to 2.85 MPa.
CONCLUSIONSandwiched osmotic pump tablet can deliver water-insoluble drug constantly for 24 hours. Release media and agitation rate scarcely affect drug release. Compared with the commercialized push-pull osmotic pump tablet, sandwiched osmotic pump tablet is easy in preparation with exempting identification of drug layer before drilling.
