Comparative study of lipophilicity from immobilized artificial chromatography and n-octanol/buffer systems.
- Author:
Jin SUN
1
;
Gang CHENG
;
Zhong-gui HE
;
Shu-jun WANG
Author Information
- Publication Type:Journal Article
- MeSH: Buffers; Chromatography, High Pressure Liquid; methods; Hydrophobic and Hydrophilic Interactions; Lipids; chemistry; Membranes, Artificial; Octanols; chemistry; Pharmaceutical Preparations; chemistry; Phospholipids; chemistry
- From: Acta Pharmaceutica Sinica 2003;38(10):791-794
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo compare lipophilicity measuring scale stemmed from immobilized artificial membrane chromatography and n-octanol/buffer systems.
METHODSA test set consisted of 27 structurally diverse compounds. The lipophilicity of these were evaluated by both immobilized artificial membrane chromatography (IAMC) and n-octanol/buffer systems, which were expressed as lg kIAM and lg DO/W,7.4, respectively.
RESULTSWith regard to each individual group, good correlation coefficient (r2) over 0.81 was obtained (0.82 for acid; 0.88 for neutral, 0.81 for base and 0.92 for ampholyte, respectively). However, a smaller r2 (0.62) was acquired for all compounds studied than that of each individual group.
CONCLUSIONIAMC and n-octanol/buffer systems were shown to be different in lipophilicity.
