Effects of 7-oxo-DHEA treatment on the immunoreactivity of BALB/c mice subjected to chronic mild stress.
- Author:
Yan-yong LIU
1
;
Nan YANG
;
Ling-na KONG
;
Ping-ping ZUO
Author Information
- Publication Type:Journal Article
- MeSH: Adjuvants, Immunologic; pharmacology; Animals; Antidepressive Agents; pharmacology; Cell Division; drug effects; Chronic Disease; Dehydroepiandrosterone; analogs & derivatives; pharmacology; Killer Cells, Natural; immunology; Male; Mice; Mice, Inbred BALB C; Stress, Physiological; blood; immunology; T-Lymphocytes; immunology; pathology; Thyroxine; blood; Triiodothyronine; blood
- From: Acta Pharmaceutica Sinica 2003;38(12):881-884
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo determine whether 7-oxo-dehydroepiandrosterone (7-oxo-DHEA) can reverse the hypoimmunity in BALB/c mice exposed to chronic mild stress.
METHODSA chronic mild stress animal model was established by subjecting BALB/c mice to a stressful regimen arranged in an unpredicted manner for 4 consecutive weeks. Immunological function alternations under chronic mild stress were assessed by lymphocytes proliferative response to mitogens and NK cell lysis activity test.
RESULTSThe studies showed the correlation between the state of depression and abnormalities in the immune response, such as a decrease of T lymphocytes proliferative response to Con A and suppression of cytotoxic of NK cell. Meanwhile, significant decrease of T3 and T4 levels was also observed. When stressed mice were daily given 7-oxo-DHEA 15 mg.kg-1, lymphocyte proliferative response and the NK cell activity were significantly enhanced and the decreased levels of T3 and T4 were restored in the stressed mice.
CONCLUSION7-oxo-DHEA can improve the depressive symptoms and hypoimmunity of BALB/c mice induced by chronic mild stress as its parent DHEA.
