Stereoselectivity in absorption of trans tramadol in rat intestine.
- Author:
Hui-chen LIU
1
;
Bao-xin LI
;
Bin DUN
;
Yong-li WANG
Author Information
- Publication Type:Journal Article
- MeSH: Analgesics, Opioid; pharmacokinetics; Animals; Duodenum; metabolism; Female; Ileum; metabolism; Intestinal Absorption; Intestine, Small; metabolism; Jejunum; metabolism; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tramadol; pharmacokinetics
- From: Acta Pharmaceutica Sinica 2003;38(12):893-896
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the stereoselectivity in absorption of trans tramadol (trans T) in rat intestine.
METHODSThe duodenum, jejunum and ileum were separately perfusated in situ with trans T dissolved in Krebs-Ringer buffer. Trans T enantiomers in the perfusate were analyzed with a high performance capillary electrophoresis (HPCE) method.
RESULTSThe absorbed fractions of trans T enantiomers were similar among the different segments of the rat intestine. The absorbed fraction of (+)-trans T was lower than that of (-)-trans T when the concentration of trans T was not higher than 40 mumol.L-1. As the concentration of trans T increased, the absorbed fractions of trans T enantiomers were reduced and the difference in absorbed fractions between trans T enantiomers became not significant.
CONCLUSIONTrans T enantiomers can be absorbed in different parts of the rat intestine. The intestinal absorption of trans T was stereoselective, (-)-trans T being preferentially absorbed.
