Genetic polymorphism of glutathione- S- trausferase M1 and T1: a systematic review in Chinese population and a pilot study in smear-positive pulmonary tuberculosis cases of Jilin province
10.3760/cma.j.issn.0254-6450.2009.05.022
- VernacularTitle:中国人群谷胱甘肽转移酶M1和T1的基因多态性分析:系统综述及吉林省结核涂阳人群研究
- Author:
Xiao-Ting LI
1
;
Yan-Li YUAN
;
Yin-Yin XIA
;
Bao-Zhu YU
;
Tie-Juan ZHANG
;
Ou LIU
;
Xiao-Zhen LV
;
Si-Yan ZHAN
Author Information
1. 北京大学医学部
- Keywords:
Glutathione-S-transferase;
Genetic polymorphism;
Tuberculosis;
Systematic review
- From:
Chinese Journal of Epidemiology
2009;30(5):502-506
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of ghitathione-S-transferase M1 (GSTM1) and T1 (GSTT1) genes polymorphisms in Chinese population and smear-positive pulmonary tuberculosis cases of Jilin province. Methods Articles about GSTM1 and GSTT1 genes polymorphisms published before 2009 in China were searched. The study population was obtained from fourteen counties (or districts) of Jilin province, which included all cases from November, 2007 to May, 2008, totally 1120. The genotypes of GSTM1 and GSTT1 were detected by multiplex PCR technique. Results The frequencies of GSTM1 and GSTT1 'null' genotypes and combination M1-T1 'null' genotype acquired from systematic review were 54.2%, 46.8% and 26.2%, respectively, in Chinese Hans they were 53.4%, 44.9% and 25.5%, and in our research they are 57.2%, 20.4% and 13.7%, respectively. No significant differences between the frequencies of males and females as well as among that of different age groups were observed(P>0.05). The frequency of GSTM1 'null' genotype in our research is slightly higher than that in systematic review (P=0.016) , and the frequencies of GSTT1 'null' genotype and combination M1-T1 'null' genotype and are significantly lower than those in systematic review (both P<0.001). Conclusion The frequencies of GSTM1 and GSTTI 'null' genotypes were different among ethnics. The statistical difference between systematic review and our research may due to our large sample size and mostly Soutbern people in previous studies.
