Effects of Mycophenolic Acid on High Glucose-induced Expression of TGF-β and CTGF in Mesangial Cells
- Author:
Yongman L(U)
1
;
Junying CHEN
;
Jufang SHAO
Author Information
1. 华中科技大学同济医学院附属同济医院
- Keywords:
mycophenolic acid;
transforming growth factor-β;
connective tissue growth factor;
mesangial cell;
diabetic nephropathy
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2006;26(3):292-293,304
- CountryChina
- Language:Chinese
-
Abstract:
The effects of mycophenolic acid (MPA) on high glucose-induced expression of transforming growth factor-β (TGF-β) and connective tissue growth factor (CTGF) in mesangial cells (MC) were investigated. Rat MC were cultured in the presence of different concentrations of MPA (1.0 and 10.0 μmol/L) or MPA plus high glucose for 72 h. The expression of TGF-β and CTGF was detected by Western blot. The results showed that high glucose could induce the expression of TGF-β and CTGF in MC, but MPA could inhibit this effects. MPA did not influence the expression of TGF-β and CTGF in normal glucose. It was concluded that MPA might prevent the progression of diabetic nephropathy by inhibiting the expression of TGF-β and CTGF in MC.
