Association of vascular endothelial growth factor 936C/T polymorphism and the susceptibility to colorectal adenoma.
- Author:
Xiang-lei WU
1
;
Dong-qing LI
;
Zhi-su LIU
;
Xin-yue WAN
;
Yun-hua WU
;
Cong-qing JIANG
;
Zhong-lin ZHANG
;
Qian-bo QIN
;
Qun QIAN
Author Information
- Publication Type:Journal Article
- MeSH: Adenoma; genetics; Adult; Case-Control Studies; Colorectal Neoplasms; genetics; Female; Genetic Predisposition to Disease; Genotype; Humans; Middle Aged; Polymorphism, Single Nucleotide; Vascular Endothelial Growth Factor A; genetics
- From: Chinese Journal of Gastrointestinal Surgery 2010;13(4):286-288
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo examine the association between polymorphism of vascular endothelial growth factor(VEGF)1498 C/T,936 C/T and colorectal adenoma genetic susceptibility.
METHODSA case-control study of 224 colorectal adenomas and 200 controls was conducted and VEGF genotypes were determined based on TaqMan-probe assay. The epidemiological factors were collected through questionnaire. Accordingly, the clinicopathological data of each sample were also investigated.
RESULTSThe carriage of 936 CT and CT+TT genotypes had significantly higher risk of colorectal adenoma (CT vs. CC, OR=2.00, 95% CI: 1.23-3.25, P=0.006; CT+TT vs. CC, OR=2.04, 95% CI:1.28-3.26, P=0.003). 936-T allele carriage had increased risk of colorectal adenoma (OR=1.91, 95% CI:1.25-2.91, P=0.003). The genotypes of 1498 C/T and the frequency of C/T allele showed no differences between healthy persons and patients (P>0.05). In patients with 936 CT+TT and 936-T allele implied a tendency of villous adenoma category (CT+TT vs. CC, OR=2.54, 95% CI:1.12-5.75, P=0.040; T allele vs. C allele, OR=3.08, 95% CI, 1.64-5.80, P=0.001).
CONCLUSIONVEGF 936 C/T polymorphism can influence susceptibility to colorectal adenoma.
