A meta-analysis of the safety of simultaneous versus staged resection for synchronous liver metastasis from colorectal cancer.
- Author:
Guo-qing CHEN
1
;
Jun LI
;
Ke-feng DING
Author Information
- Publication Type:Journal Article
- MeSH: Colorectal Neoplasms; pathology; surgery; Hepatectomy; Humans; Liver Neoplasms; secondary; surgery; Neoplasm Staging
- From: Chinese Journal of Gastrointestinal Surgery 2010;13(5):337-341
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the safety of simultaneous and staged resection for synchronous liver metastasis from colorectal cancer.
METHODSPubMed/Medline, ISI Web of Knowledge, Springer link, ebscohost, Elsevier Wiley Interscience, Google Scholar were searched for case-control studies concerning simultaneous versus staged resection of synchronous liver metastasis from colorectal cancer between January 1989 and March 2009. A meta-analysis was performed to analyze the morbidity and perioperative mortality.
RESULTSSeven case-control studies, with a total of 1390 patients of liver metastasis from colorectal cancer undergone curative hepatic resection, were reviewed. There were 495 simultaneous and 895 staged resections. Perioperative mortality was 1.1% in the staged resection group and 2.4% in the the simultaneous group, the difference was statistically significant[Peto OR 3.39, 95% CI 1.29-8.93, P=0.01]. No significant difference was found in morbidity between two groups[OR(random)0.88, 95% CI 0.51-1.51, P=0.64].
CONCLUSIONSelective staged resection is safe for synchronous liver metastasis from colorectal cancer.
