Significance of plasmic L-plastin levels in the diagnosis of colorectal cancer.
- Author:
Cheng-bin YUAN
1
;
Ren ZHAO
;
Fang-jun WAN
;
Jian-hua CAI
;
Xiao-pin JI
;
Ying-yan YU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Case-Control Studies; Colorectal Neoplasms; blood; diagnosis; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Membrane Glycoproteins; blood; Microfilament Proteins; blood; Middle Aged; Sensitivity and Specificity; Tissue Inhibitor of Metalloproteinase-1; blood
- From: Chinese Journal of Gastrointestinal Surgery 2010;13(9):687-690
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinical significance of plasmic L-plastin level in patients with colorectal cancer.
METHODSFrom March 2008 to March 2009, plasma samples were collected from 40 patients and 40 healthy controls. Plasmic L-plastin level was measured by ELISA kit and was compared to TIMP-1.
RESULTSPlasmic L-plastin level in patients with colorectal cancer was higher than that in healthy adults (1.662±0.386 vs. 0.485±0.085 μg/L, P<0.01). The sensitivity of L-plastin in the diagnosis of colorectal cancer was 67.5%, and the specificity was 80.6%. The Youden index was 0.481 and AUC was 0.772 (P<0.01). Plasmic L-plastin levels were associated with the tumor size (P=0.006), serosal penetration (F=4.687, P<0.05) and lymphatic metastasis (P<0.01). Compared to plasmic TIMP-1 level, L-plastin showed the same capability in indicating the depth of tumor. The specificity of L-plastin was better in indicating lymphatic metastasis (86% vs. 58%, χ2=4.2, P<0.05).
CONCLUSIONSPlasmic L-plastin level may serve as a potential marker in colorectal cancer.
