Association of Omi/HtrA2 expression and prognosis in patients with gastric carcinoma.
- Author:
Hong-lei CHEN
1
;
Chuang-qi CHEN
;
Jin-ping MA
;
Shi-rong CAI
;
Zhao WANG
;
Wan YANG
;
Yu-long HE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Female; High-Temperature Requirement A Serine Peptidase 2; Humans; Male; Middle Aged; Mitochondrial Proteins; genetics; metabolism; Neoplasm Staging; Prognosis; Serine Endopeptidases; genetics; metabolism; Stomach; metabolism; pathology; Stomach Neoplasms; metabolism; pathology; Young Adult
- From: Chinese Journal of Gastrointestinal Surgery 2010;13(10):766-769
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the expression of serine protease Omi/HtrA2 in gastric carcinoma tissue and its association with clinicopathological features and prognosis.
METHODSOmi/HtrA2 protein expression levels were detected by immunohistochemistry method in resected gastric carcinomas(n=68), adjacent noncancerous tissues(n=15), and normal tissues(n=15), and its association with clinicopathological features and prognosis were analyzed.
RESULTSOmi/HtrA2 expression was positive in 73.5%(50/68) of gastric cancer tissues, which was significantly higher than that in adjacent noncancerous tissues and normal tissues(P<0.05). There were no significant differences in Omi/HtrA2 expression with respect to sex, age, tumor size, and depth of invasion(all P>0.05). Omi/HtrA2 expression level was significantly associated with tumor differentiation, extent of lymph node metastasis, and tumor stage(all P<0.05). Overall 5-year survival rate of patients with gastric carcinoma was 63.3%. Five-year survival rate was higher in Omi/HtrA2 positive cases than Omi/HtrA2 negative cases(72.0% vs. 61.1%), however the difference was not statistically significant.
CONCLUSIONSOmi/HtrA2 expression is more common in gastric carcinoma. Omi/HtrA2 expression is associated with tumor differentiation, extent of lymph node metastasis, and tumor stage.
