Expression of human testis development related gene 1 in testicular cancer detected by tissue microarray.
- Author:
Hou-Yang CHEN
1
;
Jia-Ming WEN
;
Xiao-Wang XIAO
;
Dong-Jie LI
;
Xiao-Liang GUO
;
Zhi LONG
;
Ying-Bo DAI
;
Yu-Xin TANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Case-Control Studies; Child; Child, Preschool; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; genetics; metabolism; Humans; Infant; Male; Middle Aged; Molecular Sequence Data; Neoplasms, Germ Cell and Embryonal; genetics; metabolism; Protein Array Analysis; Testicular Neoplasms; genetics; metabolism; Testis; metabolism
- From: National Journal of Andrology 2010;16(10):883-886
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the protein expression of human testis development related gene 1 (TDRG1) in human testicular cancer and its pathological significance.
METHODSThe expression levels of TDRG1 were detected in the testis tissues of testicular cancer patients and normal men by tissue microarray and immunohistochemistry, and the results were analyzed.
RESULTSImmunohistochemistry exhibited positive expression of the TDRG1 protein in the testis of 73.3% (11/15) of the normal men, 83.3% (10/12) of the patients with embryonal carcinoma, 80.0% (8/10) of those with yolk sac tumor, 26.9% (7/26) of those with seminoma, and 57.1% (4/7) of those with teratoma. The expression levels of TDRG1 in the testis tissues of the seminoma and teratoma groups were shown to be significantly lower than that of the normal control (P < 0.01 and P < 0.05), but those of the embryonal carcinoma and yolk sac tumor groups exhibited no significant differences from that of the latter (P > 0.05).
CONCLUSIONThe significantly reduced expression of the TDRG1 protein in patients with seminoma or teratoma indicates that TDRG1 may be a candidate cancer suppressor gene.
