Nocturnal penile tumescence and the effect of tadalafil on erectile dysfunction.
- Author:
Fei XIAO
1
;
Zhi-An YAN
;
Xian-En GU
;
Wen-Jun BAI
;
Xiao-Feng WANG
Author Information
- Publication Type:Journal Article
- MeSH: Carbolines; pharmacology; therapeutic use; Erectile Dysfunction; drug therapy; physiopathology; Humans; Male; Penile Erection; drug effects; Tadalafil
- From: National Journal of Andrology 2010;16(10):954-958
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the correlation between the results of the nocturnal penile tumescence (NPT) test and the efficacy of tadalafil in the treatment of ED.
METHODSA total of 188 ED patients were divided into a normal NPT group (n = 136) and an abnormal NPT group (n = 52) according to the results of the NPT test. All of them were treated with tadalafil at 20 mg 3 times a week. The IIEF-5 score, SEP2, SEP3 and GAQ score were compared between the two groups before and 1 month after the treatment.
RESULTSTadalafil treatment significantly improved IIEF-5 score, SEP2 and SEP3 of both groups of the patients (P < 0.01). Compared with the abnormal NPT group, the normal NPT group showed a remarkable increase in the IIEF-5 score, SEP2, SEP3 (P < 0.05) and GAQ score (P < 0.01).
CONCLUSIONAfter 1 month of tadalafil treatment, the normal NPT group achieved a more significant improvement of erectile function and sexual satisfaction than the abnormal NPT group, suggesting that tadalafil has a better therapeutic effect for ED patients with normal NPT.
