Testicular dysgenesis syndrome: an update.
- Author:
Zhe-Ming XU
1
;
Da-Xing TANG
Author Information
1. Department of Urology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China. alfh19@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Cryptorchidism;
Gonadal Dysgenesis;
etiology;
genetics;
Humans;
Male;
Testicular Diseases;
etiology;
genetics;
Testicular Neoplasms
- From:
National Journal of Andrology
2010;16(12):1113-1116
- CountryChina
- Language:Chinese
-
Abstract:
Researches on the testicular dysgenesis syndrome (TDS) have flourished in the recent decade, and a widely accepted view on its pathogenesis is that environmental endocrine disrupting chemicals (EDCs) act on Leydig cells and/or testicular Sertoli cells, resulting in abnormal development of the testis and leading to the symptoms of TDS. Molecular biological studies suggest a correlation of TDS etiology with insulin-like factor 3 (INSL-3), androgen receptor (AR), P27kip, WT-1 and Müllerian inhibiting substance (MIS). This review focuses on the progress in current researches on the etiology and mechanism of TDS.
