Karyotype analysis of qualified sperm donors on preliminary screening.

Author: Hong-chuan NIE ¹ ; Yue-qiu TAN ; Guang-xiu LU
Author Information

1. Institute of Reproduction and Stem Cell Engineering, Human Sperm Bank, Citic-Xiangya Hospital of Reproduction and Genetics, Central South University, Changsha, Hunan 410078, China. niehongchuan@gmail.com
Publication Type:Journal Article
MeSH: Adult; Chromosome Aberrations; Chromosome Disorders; prevention & control; Genetic Testing; Gonadal Dysgenesis, 46,XY; genetics; prevention & control; Humans; Karyotyping; Male; Sperm Banks; Tissue Donors; Young Adult
From: National Journal of Andrology 2011;17(1):13-16
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo explore the significance of karyotype analysis in screening sperm donors.
METHODSFrom January 1, 2004 to December 31, 2008, a total of 2537 potential sperm donors passed our preliminary screening, and all were routinely karyo-typed via peripheral blood. Follow-ups were conducted on the pregnancy outcome and congenital malformation after artificial insemination with the sperm from the qualified donors.
RESULTSAmong the 2537 qualified sperm donors, 2362 were of the normal karyotype 46, XY and 135 showed polymorphism. Abnormal karyotype was found in 6 cases, and controversial abnormal karyotype in 34.
CONCLUSIONKaryotype analysis can reduce the risk of chromosomal disease in neonates from artificial insemination, and genetic counseling for abnormal karyotype sperm donors may help them solve their future reproductive problems.