Transurethral resection of the prostate for advanced hormone-refractory prostate cancer: a feasibility study.
- Author:
Jian-xun YANG
1
;
Qi-zhong FU
;
Guang-yao LÜ
;
Sheng-fang DONG
;
Ying LIU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Feasibility Studies; Humans; Male; Middle Aged; Prostatic Neoplasms; surgery; Transurethral Resection of Prostate; Treatment Outcome; Urinary Bladder Neck Obstruction; surgery
- From: National Journal of Andrology 2011;17(1):55-58
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of transurethral resection of the prostate (TURP) in the treatment of advanced prostate cancer with bladder outlet obstruction (BOO).
METHODSWe included in this study 43 cases of advanced prostate cancer with BOO treated by TURP, and analyzed their IPSS, maximum urinary flow rate and relevant risk factors pre-operatively and at 3 and 12 months after TURP.
RESULTSCompared with the baseline, IPSS and the maximum urinary flow rate of the patients showed significant differences 3 months after surgery ([19.60 +/- 0.41] score vs. [9.58 +/- 0.33] score, [4.93 +/- 0.68] ml/s vs. [8.96 +/- 0.47] ml/s, P < 0.05), but not at 12 months ([15.73 +/- 0.66] score, [5.67 +/- 0.44] ml/s). In multiple regression analysis, a good outcome was associated with pre-operative acute urinary retention, while poor prognosis with hormone-refractory prostate cancer.
CONCLUSIONIn the treatment of advanced hormone-refractory prostate cancer with BOO, TURP can reduce IPSS and increase the maximum urinary flow rate in the early period after surgery, but its long-term effect is not so desirable. Meanwhile the operation itself may bring about relevant complications and reduce the patient's quality of life.
