Effects of Shengmai injection on testicular injury after torsion/detorsion in rats of different ages.
- Author:
Yi-fu ZHOU
1
;
Chun-chao NI
;
Ting-ting ZHENG
;
Nai-jing XU
;
Yu WANG
;
Jing-jing YU
;
Jin-ping ZHANG
;
Gui-shan GAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drug Combinations; Drugs, Chinese Herbal; therapeutic use; Male; Malondialdehyde; metabolism; Phytotherapy; Rats; Rats, Sprague-Dawley; Reperfusion Injury; prevention & control; Spermatic Cord Torsion; drug therapy; metabolism; Superoxide Dismutase; metabolism; Testis; drug effects; injuries; metabolism
- From: National Journal of Andrology 2011;17(2):185-188
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the different effects of Shengmai injection on testicular injury after testis torsion/detorsion in rats of different ages.
METHODSSixteen healthy male SD rats aged 3, 6 and 12 weeks were equally randomized into an experimental group (testicular torsion/detorsion plus Shengmai injection) and a control group (testicular torsion/detorsion plus saline). The rat models of testicular torsion were killed 24 h after surgery for the measurement of total antioxidant capacity (T-AOC), superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in the testis.
RESULTSCompared with the controls, the 3- and 6-week-old rats of the experimental group showed no significant changes in T-AOC, SOD activity and MDA content (P > 0.05), while the 12-week-old experimental rats exhibited a remarkable increase in SOD and T-AOC and an obvious decrease in MDA content (P < 0.05).
CONCLUSIONShengmai injection has a protective effect against acute ischemia-reperfusion testicular injury after torsion/detorsion in rats, but the effect varies with the age, more obvious in older ones.
