TRAIL gene polymorphism and genetic susceptibility to prostate cancer in the Chinese Han population of Nanjing.
- Author:
Yuan-yuan MI
1
;
Jiu-ming LI
;
Ning SHAO
;
Zhi-chao MIN
;
Bin XU
;
Li-xin HUA
;
Ning-han FENG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Asian Continental Ancestry Group; genetics; Case-Control Studies; China; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Prostatic Neoplasms; genetics; TNF-Related Apoptosis-Inducing Ligand; genetics
- From: National Journal of Andrology 2011;17(3):242-246
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the correlation between the polymorphism of the tumor necrosis factor-related apoptosis inducing ligand (TRAIL) and the genetic susceptibility to prostate cancer (PCa) in the Chinese Han population in Nanjing.
METHODSWe performed a case control study on 187 cases of PCa and 237 cancer-free healthy controls. Peripheral blood genome DNA was extracted from the subjects for analysis of the polymorphism of the TRAIL-716 locus by polymerase chain reaction-ligase detection reaction (PCR-LDR). The correlations between the susceptibility to PCa and different genotypes were compared.
RESULTSAn SNP (-716A/G) was found in the promoter of the TRAIL gene. AA, AG and GG genotypes were identified. Logistic regression analysis suggested that AG, GG and AG + GG genotypes had no significant correlation with the risk of PCa (OR = 0.89, 95% CI = 0.54 -1.47; OR = 0.94, 95% CI = 0.69 -1.27; OR = 0.87, 95% CI = 0.54 - 1.41).
CONCLUSIONThe TRAIL-716 polymorphism is not directly related with the genetic susceptibility to PCa in the Chinese Han population of Nanjing.
