Multi-slice CT contrast-enhanced presentations of advanced gastric cancer: associations with histo-differentiation and expression of p53 and P-glycoprotein.
- Author:
Xin-dao YIN
1
;
Jian-hua ZHAO
;
Lin ZHANG
;
Li-ping WANG
;
Ling-quan LU
;
Li-wei WANG
;
Guang-hui XIE
;
Qian-zhi WU
;
Shu-zhi WANG
;
Jian-ping GU
Author Information
- Publication Type:Journal Article
- MeSH: ATP-Binding Cassette, Sub-Family B, Member 1; metabolism; Adult; Aged; Aged, 80 and over; Female; Humans; Immunohistochemistry; Male; Middle Aged; Stomach Neoplasms; diagnostic imaging; metabolism; pathology; Tomography, X-Ray Computed; methods; Tumor Suppressor Protein p53; metabolism
- From: Chinese Medical Journal 2008;121(24):2487-2491
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDThis study aimed to investigate multi-slice CT contrast-enhanced presentation of gastric cancer and its correlation with histo-differentiation and p53 and P-glycoprotein (P-gp) expression.
METHODSSixty-six patients with gastric cancer in the present study underwent a multi-slice CT preoperative routine and dual-phase contrast-enhanced examination of the upper abdomen; postoperative specimens were used to determine histo-differentiation and the expression of p53 and P-gp. The correlation of multi-slice CT contrast-enhanced presentation with histo-differentiation and expression of p53 and P-gp was analyzed.
RESULTSThe dual-phase contrast-enhanced ratio (CER) was not correlated with the histo-differentiation of gastric cancer (P > 0.05). Positive expression of p53 and P-gp was significantly higher in the cases of layered or heterogeneous enhancement than in the cases of homogenous enhancement (P < 0.05). Positive expression of p53 was also correlated with the arterial phase CER, tumor size and lymph node metastasis (P < 0.05), but not with infiltration thickness of the gastric wall, nor was it correlated with the portal phase CER (P > 0.05). Positive expression of P-gp was only correlated with the portal phase CER (P = 0.005).
CONCLUSIONSDifferently enhanced pattern and CER of the arterial and portal phase in gastric cancer correlate with its different histo-differentiation and expression of p53 and P-gp respectively. In addition, tumor size and lymph node metastasis of gastric cancer relate to the expression of p53.
