Cyclooxygenase-2 Polymorphisms and Susceptibility to Colorectal Cancer: A Meta-Analysis.
10.3349/ymj.2013.54.6.1353
- Author:
Jun WANG
1
;
Xufeng GUO
;
Jixiang ZHANG
;
Jia SONG
;
Mengyao JI
;
Shijie YU
;
Jing WANG
;
Zhuo CAO
;
Weiguo DONG
Author Information
1. Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China. dwg@whu.edu.cn
- Publication Type:Original Article ; Meta-Analysis
- Keywords:
Colorectal cancer;
cyclooxygenase-2;
polymorphism;
meta-analysis
- MeSH:
Asian Continental Ancestry Group;
Case-Control Studies;
Colorectal Neoplasms/*genetics;
Cyclooxygenase 2/*genetics;
Genetic Predisposition to Disease/genetics;
Humans;
Polymorphism, Genetic/*genetics
- From:Yonsei Medical Journal
2013;54(6):1353-1361
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Four polymorphisms, -765G>C, -1195G>A, 8473T>C, and Val511Ala, in the cyclooxygenase-2 (COX-2) gene were identified to be associated with colorectal cancer (CRC) risk. However, the results are inconsistent. The objective of this meta-analysis was to evaluate the association between these four polymorphisms and the risk of CRC. MATERIALS AND METHODS: All eligible case-control studies published up to December 2012 on the association between the four polymorphisms of COX-2 and CRC risk were identified by searching PubMed and Web of Science. The CRC risk associated with the four polymorphisms of the COX-2 gene was estimated for each study by odds ratio (OR) together with its 95 % confidence interval (CI), respectively. RESULTS: A total of 15 case-control studies were included. Overall, no evidence has indicated that the -1195A allele, -765C allele, 8473C allele, and 511Ala allele are associated with susceptibility to CRC (-1195G>A: OR=1.11, 95 % CI: 0.82-1.51, p=0.78; -765G>C: OR=1.08, 95 % CI: 0.96-1.21, p=0.07; 8473T>C: OR=1.03, 95 % CI: 0.89-1.18, p=0.91; Val511Ala: OR=0.71, 95 % CI: 0.46-1.09, p=0.94). However, stratified analysis with ethnicity indicated that individuals with -765GC or GC/CC genotypes had an increased risk of CRC among Asian populations (GC vs. GG: OR=1.05, 95 % CI: 0.87-1.28, p=0.03; GC+CC vs. GG: OR=1.08, 95 % CI: 0.96-1.21, p=0.07). CONCLUSION: This meta-analysis indicated that -765G>C polymorphism was significantly associated with susceptibility to CRC in Asian populations.
