Dipeptidyl Peptidase 10, a Novel Prognostic Marker in Colorectal Cancer.
10.3349/ymj.2013.54.6.1362
- Author:
Heae Surng PARK
1
;
Hyun Yang YEO
;
Hee Jin CHANG
;
Kyung Hee KIM
;
Ji Won PARK
;
Byung Chang KIM
;
Ji Yeon BAEK
;
Sun Young KIM
;
Dae Yong KIM
Author Information
1. Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Colorectal cancer;
dipeptidyl peptidase 10;
progression;
prognosis
- MeSH:
Colorectal Neoplasms/*metabolism/*pathology;
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/*metabolism;
Disease Progression;
Female;
Humans;
Immunohistochemistry;
Male;
Prognosis;
Tumor Markers, Biological/*metabolism
- From:Yonsei Medical Journal
2013;54(6):1362-1369
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The dipeptidyl peptidase IV (DPPIV) gene family exhibits multiple functions and is involved in the pathogenesis of various diseases. It has attracted pharmaceutical interest in the areas of metabolic disorders as well as cancer. However, clinicopathologic significance of DPPIV family in colorectal cancer is not fully understood. MATERIALS AND METHODS: The clinical relevance of DPPIV and DPP10 expression was determined by immunohistochemical staining, and by assessing its clinicopathologic correlation in 383 colorectal cancer patients with known clinical outcomes. RESULTS: DPPIV was not expressed in normal colon mucosa, but it showed luminal expression in 52 of the 383 colorectal cancers (13.5%). DPPIV expression in tumors was associated with right-sided location of the colon (p=0.010) and more advanced tumor stage (p=0.045). DPP10 was expressed in normal colonic mucosa, but its expression varied in primary colorectal cancer tissues. Loss of DPP10 expression was found in 11 colorectal cancers (CRCs) (2.9%), and multivariate analysis showed that loss of DPP10 expression was an independent factor for poor patient prognosis (p=0.008). CONCLUSION: DPP10 may play a role in disease progression of colorectal cancer and loss of DPP10 expression in primary CRC is significantly associated with poor survival outcomes.
