Expression of psoriasin in mycosis fungoides and its significance.
- Author:
Lei XU
1
;
Wei-hui ZENG
;
Yan ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; CD4-Positive T-Lymphocytes; physiology; Chemotaxis; physiology; Female; Humans; Male; Middle Aged; Mycosis Fungoides; etiology; metabolism; S100 Calcium Binding Protein A7; S100 Proteins; metabolism; Skin; metabolism; Young Adult
- From: Journal of Southern Medical University 2011;31(11):1907-1909
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the role of psoriasin in mycosis fungoides.
METHODSPsoriasin protein expressions in normal skin tissues and mycosis fungoides tissues were detected by immunohistochemistry.
RESULTSPsoriasin protein was not expressed in normal skin tissues. In 21 mycosis fungoides tissue specimens, psoriasin was expressed in the stratum corneum and stratum spinosum but not in the stratum basale, with a positivity rate of 90.5% in these specimens. Psoriasin expression was significantly higher in mycosis fungoidesa tissues than in normal tissues (P<0.001).
CONCLUSIONPsoriasin may play a role in the pathogenesis of mycosis fungoides by chemotaxis of CD4+ T lymphocytes.
