Pharmacokinetics of amphotericin B in the cerebrospinal fluid during continuous intrathecal administration for treatment of cryptococcal neoformans meningitis.
- Author:
Min FANG
1
;
Tian-ming LV
;
Yuan YAN
;
Shi-ting LIU
;
Wen-hui GAO
;
Xiao-jia LIU
;
Jia YIN
;
Li WANG
;
Yuan-yuan WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Amphotericin B; administration & dosage; pharmacokinetics; Antifungal Agents; administration & dosage; pharmacokinetics; Cerebrospinal Fluid; metabolism; Cryptococcus neoformans; isolation & purification; Female; Humans; Infusions, Spinal; methods; Male; Meningitis, Cryptococcal; drug therapy; metabolism
- From: Journal of Southern Medical University 2011;31(11):1929-1931
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the pharmacokinetics of amphotericin B (AMB) in the cerebrospinal fluid (CSF) during continuous intrathecal administration of AMB for treatment of cryptococcal neoformans meningitis (CNM).
METHODSThe concentration of AMB in the CSF was measured using reversed phase high performance liquid chromatography (RP-HPLC) in 3 patients receiving continuous intrathecal infusion of AMB for CNM.
RESULTSAMB concentrations in the CSF of the 3 patients exceeded the minimal inhibitory concentration (MIC) of AMB against Cryptococcus neoformans. The concentration-time curve showed that AMB concentration in the CSF underwent obvious variations on the first day of intrathecal infusion and after additional AMB doses, but maintained a stable level (0.61-1.21 µg/ml) on the next day.
CONCLUSION[corrected] Continuous intrathecal administration of AMB can enhance the drug concentration in the CSF and maintain a stable and effective drug level for treatment of CNM.
