Efficacy of gadobenate dimeglumine vs gadopentetate dimeglumine in contrast- enhanced magnetic resonance imaging for diagnosis of solitary brain metastases.
- Author:
Qing-jun WANG
1
;
Yong WANG
;
Xian XU
;
Hui XIAO
;
Lin MA
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Brain Neoplasms; diagnosis; pathology; secondary; Breast Neoplasms; pathology; Contrast Media; Female; Gadolinium DTPA; Humans; Image Enhancement; methods; Lung Neoplasms; pathology; Magnetic Resonance Imaging; methods; Male; Meglumine; analogs & derivatives; Middle Aged; Organometallic Compounds
- From: Journal of Southern Medical University 2011;31(12):1968-1973
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare gadobenate dimeglumine (Gd-BOPTA) and gadopentetate dimeglumine (Gd-DTPA) for their efficacy as contrast agents in contrast-enhanced magnetic resonance imaging (MRI) for diagnosis of solitary brain metastases (SBM).
METHODSWe conducted an intra-individual study of contrast-enhanced T1-weighted MRI (T(1)WI) data from 27 Chinese patients with suspected SBM to compare the enhancement findings of two different MRI contrast agents, Gd-BOPTA and Gd-DTPA (at equivalent doses of 0.1 mmol/kg), for the detection of SBM. All the patients underwent two identical MRI examinations on a 3.0-T MRI scanner first with Gd-DTPA and then with Gd-BOPTA. Evaluation of the contrast enhancement was performed qualitatively (border delineation, extent, internal morphology, and contrast enhancement) and quantitatively (lesion-to-brain ratio, contrast-to-noise ratio, and percent enhancement) by 3 independent, fully blinded, and highly experienced neuroradiologists.
RESULTSQualitative assessment by readers revealed a significant overall preference (P<0.05) for Gd-BOPTA over Gd-DOTA in terms of lesion border delineation, extent, lesion internal morphology, and contrast enhancement. Quantitative assessment also revealed a significant better performance of Gd-BOPTA in light of lesion-to-brain ratio (P<0.05), contrast-to-noise ratio (P<0.05), and percent enhancement (P<0.05).
CONCLUSIONAt an equivalent dose, Gd-BOPTA allows better contrast enhancement of SBM than Gd-DTPA in MRI.