Assessment of the mechanical properties and biocompatibility of a new electrospun polyurethane vascular prosthesis.
- Author:
Wei HE
1
;
Zuo-jun HU
;
An-wu XU
;
Heng-hui YIN
;
Jin-song WANG
;
Jie-lian YE
;
Shen-ming WANG
Author Information
- Publication Type:Journal Article
- MeSH: Biocompatible Materials; chemistry; Blood Vessel Prosthesis; Cell Adhesion; Humans; Materials Testing; Mechanical Phenomena; Polyurethanes; chemistry; Porosity; Prosthesis Design; Tensile Strength
- From: Journal of Southern Medical University 2011;31(12):2006-2011
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo develop a small-caliber vascular grafts and study its morphologies, mechanical properties and biocompatibility.
METHODSThe effects of electrospinning conditions on the microstructure and porosity of the resulting scaffolds were investigated for preparation of a small-caliber (4 mm) polyurethane vascular grafts with optimum microstructures and mechanical properties. The mechanical properties and biocompatibility of the prepared grafts were evaluated.
RESULTSThe polyurethane vascular grafts showed a three-dimensional reticular structure consisting of nanofibers, with an average porosity of (51.48∓4.47)% and tensile strength of 5.85 ∓ 0.62 MPa. The grafts provided a better long-term support than e-PTFE graft for endothelial cell growth and endothelialization.
CONCLUSIONThe polyurethane vascular prosthesis possessed favorable microstructures, excellent mechanical properties and good biocompatibility for potential clinical application.
