Effect of CD40 blockade on acute renal graft rejection in rats.
- Author:
Xiang-hua SHI
1
;
Xiao-you LIU
;
Xu-yong SUN
;
Ming ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antibodies, Monoclonal; pharmacology; therapeutic use; CD40 Antigens; antagonists & inhibitors; immunology; CD40 Ligand; immunology; Female; Graft Rejection; drug therapy; prevention & control; Graft Survival; drug effects; Kidney Transplantation; adverse effects; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar
- From: Journal of Southern Medical University 2011;31(12):2085-2086
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effect of CD40 blockade in suppressing acute rejection of renal graft in rats.
METHODSWith Wistar rats as the donor and male SD rats as the recipients, rat models of acute renal graft rejection was established. The rat models were divided into therapy group and control group, and in the former group, CD40 ligand (CD40L) monoclonal antibody was injected daily for 4 consecutive days starting on the next day following kidney transplantation. On day 5 after the transplantation, the renal graft was harvested for histological examination, and graft rejection was evaluated semiquantitatively.
RESULTSThe mean semiquantitative score of the renal graft was 0.63∓0.52 in the therapy group, significantly lower than that of the control group (3.72∓1.48, P<0.05).
CONCLUSIONCD40L monoclonal antibody can inhibit acute renal graft in rats.
