Clinical significance of blood and fecal tumor M2-pyruvate kinase expression in patients with colorectal cancer.
- Author:
Yong LI
1
;
Jun-jiang WANG
Author Information
- Publication Type:Journal Article
- MeSH: Biomarkers, Tumor; metabolism; Case-Control Studies; Colorectal Neoplasms; blood; metabolism; Feces; enzymology; Female; Humans; Male; Pyruvate Kinase; blood; metabolism
- From: Journal of Southern Medical University 2011;31(12):2087-2089
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the clinical significance of blood and fecal expression of tumor M2-pyruvate kinase (Tumor M2-PK) in patients with colorectal cancer.
METHODSWith 22 healthy subjects as controls, 44 patients with CRC were examined for tumor M2-PK in serum and fecal samples using a sandwich enzyme immunoassay.
RESULTSThe sensitivity of serum and fecal tumor M2-PK for detecting CRC was 59.1% and 63.6% with a specificity of 86.4% and 81.8%, respectively. The serum and fecal levels of tumor M2-PK showed a significant correlation in CRC patients.
CONCLUSIONTumor M2-PK has good sensitivity and specificity in the diagnosis of CRC.
