Effect of CO(2) pneumoperitoneum on renal function in rats.
- Author:
Zhanping XU
1
;
Xiaoyong PU
;
Huanqing YANG
;
Xiangguang ZHENG
;
Jiumin LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Carbon Dioxide; Female; Kidney; physiology; Kidney Transplantation; Laparoscopy; methods; Male; Nephrectomy; methods; Pneumoperitoneum, Artificial; adverse effects; methods; Rats; Rats, Sprague-Dawley; Retroperitoneal Space; surgery; Time Factors; Tissue and Organ Harvesting; methods
- From: Journal of Southern Medical University 2012;32(1):119-121
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effects of different CO(2) pneumoperitoneum conditions on renal function in rats and provide experimental evidence for improving renal graft function after transplantation.
METHODSSD rats were randomized into 10 groups (n=12) and subject to CO(2) pneumoperitoneum at different pressures (0.67, 1.33 and 2.0 kPa) for 60 or 120 min. Serum urea nitrogen (BUN), creatinine (Cr) and N-acetyl-β-D-glocosaminidase (NAG) levels were detected after pneumoperitoneum.
RESULTSAs the pressure and time of pneumoperitoneum increased, the renal function deteriorated gradually, showing significant differences between the groups (P<0.05).
CONCLUSIONIncreased pressure and prolonged duration of CO(2) pneumoperitoneum causes impairment of the renal function, suggesting the necessity of reducing the operative time and lowering the pressure of pneumoperitoneum when harvesting renal graft in living donors.
