Genistein attenuates monocrotaline-induced pulmonary arterial hypertension in rats by up-regulating heme oxygenase-1 expression.
- Author:
Yukun ZHANG
1
;
Daoxin WANG
;
Tao ZHU
;
Changyi LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Genistein; pharmacology; therapeutic use; Heme Oxygenase (Decyclizing); metabolism; Hypertension, Pulmonary; chemically induced; drug therapy; enzymology; Lung; enzymology; pathology; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Up-Regulation; drug effects
- From: Journal of Southern Medical University 2012;32(2):151-154
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of genistein on the expression of heme oxygenase-1 (HO-1) in rats with pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT).
METHODSSixty male Sprague-Dawley rats were randomly divided into 4 groups (n=15), namely the control group, model group, low-dose (20 µg/kg) genistein group and high-dose (80 µg/kg) genistein group. The hemodynamic parameters were measured and the remodeling of pulmonary small arteries was observed by electron microscope (EM). The expression of HO-1 in the lung tissues were detected by Western blotting.
RESULTSCompared with the model group, genistein treatment significantly reduced the elevated mean pulmonary arterial pressure, improved the right ventricular hypertrophy index, and increased the expression of HO-1 in a dose-dependent manner.
CONCLUSIONGenistein attentuates pulmonary arterial hypertension in MCT-treated rats possibly by up-regulation of HO-1 in the lung tissues.
