Expression and prognostic value of MTDH, Bcl-2 and E-cadherin in sinonasal malignant mucosal melanoma

VernacularTitle:异黏蛋白、Bcl-2和上皮型钙黏蛋白在鼻黏膜恶性黑色素瘤中的表达及意义
Author: Bingqing ZOU ¹ ; Shuyi WANG
Author Information

1. 复旦大学附属眼耳鼻喉科医院病理科
Keywords: Nose neoplasms; Melanoma; Cell adhesion molecules; Bcl-2-associated X protein; Cadherins; Prognosis
From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2015;50(12):1009-1014
CountryChina
Language:Chinese
Abstract: Objective To study the expression and predictive value of MTDH, Bcl-2 and E-cadherin in sinonasal malignant mucosal melanoma (SNM).Methods Seventv-four fonnalin-fixed paraffin-embedded SNM specimens were subjected to immunohistochemical staining of MTDH, Bcl-2 and E-cadherin.Correlation between staining results and disease outcome was analvzed.SPSS 19.0 software was used to analyze the data.Results Positive staining of MTDH, Bcl-2 and E-cadherin was observed in 56/74 (75.7％), 18/74 (24.3％) and 21/74 (28.4％) cases, respectively.MTDH positive patients had higher metastatic rate than MTDH negative patients (67.9％ vs.33.3％ , P =0.009, OR =2.037, 95％ CI: 1.034-4.016).Negative Bcl-2 was correlated with worse overall survival time (HR =2.023, P =0.025).Expression of E-cadherin was adversely associated with expression of MTDH (r =-0.315, P =0.006).Conclusion High MTDH expression and low Bcl-2 expression suggest poor prognosis of SNM, while the predictive value of E-cadherin needs further study.