Treatment and outcome of recurrent cervical lymph nodes in patients with nasopharyngeal carcinoma after radiotherapy.
- Author:
Yongli WANG
1
;
Guiping LAN
1
;
Yongfeng SI
1
;
Zhuoxia DENG
1
;
Jinjie SUN
1
;
Yong YANG
1
;
Xing HAN
1
;
Jingjin WENG
1
;
Fuling ZHOU
1
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma; Humans; Kaplan-Meier Estimate; Lymph Nodes; pathology; Nasopharyngeal Neoplasms; radiotherapy; Neck; Neck Dissection; Neoplasm Recurrence, Local; surgery; Prognosis; Proportional Hazards Models; Retrospective Studies; Survival Rate; Treatment Outcome
- From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2016;51(3):183-188
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacies of different treatments for recurrent cervical lymph nodes and the factors contributing to prognosis in patients with nasopharyngeal carcinoma after radiotherapy.
METHODSClinical data of 79 patients with nasopharyngeal carcinoma after radiotherapy were retrospectively analyzed, and all cases were diagnosed as having recurrent cervical lymph nodes by pathological examination. The factors including sex, age, the interval between completion of radiotherapy and recurrence, rN stage, treatment methods, and the location relationship between recurrent lesion and primary tumor in the neck were analyzed for prognosis. Kaplan-Meier curves, Log-rank test and Cox's proportional hazards regression mode were used in the statistical analysis.
RESULTSThe median recurrence time was 26 months, and the 1- , 3- and 5-year overall survival rates were 77.9%, 53.4% and 39.7%. Cox's proportional hazards regression mode analysis indicated that age, rN stage, treatment methods, and the location relationship between recurrent lesion and primary tumor were significantly prognostic factors.
CONCLUSIONSNeck dissection is superior to re-radiotherapy in treatment of recurrent cervical lymph nodes in nasopharyngeal carcinoma after radiotherapy. The patients younger than 45 years old, in early rN stage and for recurrence in the center region of primary tumor have a better prognosis.