Effect of CD14 promoter variants on the susceptibility to laryngeal cancer.
- Author:
Lijuan YANG
1
;
Shuxin WEN
1
;
Jia LIN
2
;
Xuemei ZHANG
2
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; Case-Control Studies; Genetic Predisposition to Disease; Genotype; Humans; Laryngeal Neoplasms; genetics; Lipopolysaccharide Receptors; genetics; Odds Ratio; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Promoter Regions, Genetic
- From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2016;51(3):197-202
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of -260C>T and -651C>T genetic variants in the promoter region of CD14 on the susceptibility to laryngeal cancer.
METHODSA total of 163 patients with laryngeal cancer and 326 healthy subjects as controls were included. Genotypes of CD14 -260C>T (rs2569190) and -651C>T (rs5744455) variants were determined by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). Odd ratios (OR) and 95% confidence intervals (95%CI) were calculated with logistic regression analysis.
RESULTSCompared with CD14 -651CC genotype carriers, -651TT genotype carriers had the increased risk of laryngeal cancer with the OR (95%CI) of 5.79 (2.38-14.11). When the -651TT genotype carriers were stratified by smoking status, the OR (95%CI) for laryngeal cancer was 8.64 (1.88-39.77) in nonsmokers and 4.74 (1.69-13.25) in smokers; the OR (95%CI) was 5.40 (1.10-26.45) in the light smokers and 4.30 (1.10-16.75) in the hevey smokers. When the -651TT genotype carriers were stratified by drinking status, the OR (95%CI) for laryngeal cancer was 6.48 (2.81-14.95) in nondrinkers and 2.01 (0.65-6.26) in drinkers. There was no significant difference in CD14 -260C>T genotype distribution between patients and controls.
CONCLUSIONPolymorphisms of -651C>T in CD14 promoter contribute to the susceptibility to laryngeal cancer in Chinese population.
