Cl⁻ channels: what role do they play in mammalian heart?
- Author:
Shi-Sheng ZHOU
1
Author Information
1. Institute of Basic Medical Sciences, Department of Physiology, Medical College, Dalian University, Dalian 116622, China. zhouss@dlu.edu.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Calcium Channels;
physiology;
Cations;
metabolism;
Chloride Channels;
physiology;
Heart;
physiology;
Humans;
Potassium Channels;
physiology;
Sodium Channels;
physiology;
TRPM Cation Channels;
physiology
- From:
Acta Physiologica Sinica
2006;58(2):104-109
- CountryChina
- Language:English
-
Abstract:
Cl(-) channel has been identified in heart over more than a decade. It is now known that Cl(-) channel is a super-family. The potentially important roles of cardiac Cl(-) channels have been emerging. Cardiac Cl(-) channels may play multifunctional roles in both physiological and pathophysiological conditions. Since the existence and distribution of cardiac Cl(-) channels vary with species and cardiac tissues, and blockade of Cl (-) channel with putative Cl(-) channel blockers or Cl(-) substitution has profound influence on cardiac electrical properties, it appears that the main role of cardiac Cl(-) channels may be to modulate cation channels or provide an ionic environment suitable for the activities of cation channels. So, to investigate the relationship between Cl(-) channels and cation channels may be of physiological and pathophysiological significance.
