Oligomeric interaction between ryanodine receptors: potential role in Ca(2+) release.
- Author:
Xiao-Fang HU
1
;
Pei-Hong ZHU
;
Jun HU
Author Information
1. College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, China. xfhu@sjtu.edu.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Calcium;
metabolism;
Cations;
Humans;
Muscle, Skeletal;
drug effects;
metabolism;
Receptor Cross-Talk;
physiology;
Ryanodine Receptor Calcium Release Channel;
physiology;
Sarcoplasmic Reticulum;
metabolism
- From:
Acta Physiologica Sinica
2006;58(4):305-308
- CountryChina
- Language:English
-
Abstract:
Receptor proteins in both eukaryotic and prokaryotic cells often form regular lattice or array in the membrane. Recent theoretical analyses indicate that such arrays may provide a novel mechanism for receptor signaling regulation in cells. The functional coupling between neighboring receptors could improve the signaling performance. The ryanodine receptors (RyR)/calcium release channels usually form 2-D regular lattice in the endoplasmic/sarcoplasmic reticulum membranes. Thus, RyR is a potentially good model to study the function of receptor 2-D array. In this article, we briefly review recent progresses in this research field, including RyR-RyR interaction, RyR array's function and working mechanisms. The investigations performed by new methods in our laboratory are summarized. We demonstrate that the RyR-RyR interaction is modulated by the functional states of RyRs. Accordingly, the mechanism of "dynamic coupling" of RyR array is proposed. Its possible role in RyR-mediated Ca(2+) release is discussed.
