Forced running enhances neurogenesis in the hippocampal dentate gyrus of adult rats and improves learning ability.
- Author:
Wei-Ping XU
1
;
Li-Dong SHAN
;
Shan GONG
;
Lin CHEN
;
Yue-Jin ZHANG
;
Qi-Zhang YIN
;
Tadashi HISAMITSU
;
Xing-Hong JIANG
;
Shi-Yu GUO
Author Information
1. Department of Neurobiology, School of Medicine, Soochow University, Suzhou 215123, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Bromodeoxyuridine;
metabolism;
Cell Survival;
Dentate Gyrus;
cytology;
physiology;
Intermediate Filament Proteins;
analysis;
Learning;
Male;
Maze Learning;
Nerve Tissue Proteins;
analysis;
Nestin;
Neurons;
physiology;
Physical Conditioning, Animal;
Rats;
Rats, Sprague-Dawley;
Running
- From:
Acta Physiologica Sinica
2006;58(5):415-420
- CountryChina
- Language:English
-
Abstract:
To investigate the effect of forced running in motor-driven wheel on neurogenesis in the hippocampal dentate gyrus (DG) of adult rats, 5-bromo-2-deoxyuridine (BrdU), a thymidine analog was applied to mark cell proliferation. Neuroepthelial stem cell protein (nestin) expression was used to identify neural stem/precursor cells. The BrdU- and nestin-positive cells were examined by immunohistochemical technique. The ability of learning was evaluated by Y-maze test to explore the functional role of the newborn cells in the DG after forced running. It was found that the number of BrdU- and nestin-positive cells in the DG in running groups was significantly increased compared to that in the control group (P<0.05). The effect of forced running on neurogenesis was intensity-dependent. In addition, an improvement of learning ability in Y-maze test was observed after forced running. These findings suggest that forced running in motor-driven wheel could enhance neurogenesis in the hippocampal DG of adult rats and improve learning ability.
