Effects of sodium salicylate on the expressions of gamma-aminobutyricacid and glutamate and auditory response properties of the inferior colliculus neurons.
- Author:
Shi-Hua YIN
1
;
An-Zhou TANG
;
Xiao-Ling XING
;
Song-Hua TAN
;
Li-Hong XIE
Author Information
1. Department of Otorhinolaryngology, First Clinical College, Guangxi University of Medical Sciences, Nanning 530021, China. shihuayin@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Acoustic Stimulation;
Animals;
Female;
Glutamates;
analysis;
Glutamic Acid;
analysis;
Immunohistochemistry;
Inferior Colliculi;
chemistry;
drug effects;
physiology;
Male;
Mice;
Reaction Time;
drug effects;
Sodium Salicylate;
pharmacology;
gamma-Aminobutyric Acid;
analysis
- From:
Acta Physiologica Sinica
2006;58(5):449-455
- CountryChina
- Language:Chinese
-
Abstract:
The effects of sodium salicylate (NaSA) on the expressions of gamma-aminobutyricacid (GABA) and glutamate (Glu), and auditory response properties of the inferior colliculus neurons in mice were studied. Thirty-six Kunming mice were divided into three groups: control group (saline injection); NaSA group (NaSA 450 mg/kg, i.p., each day for 15 d); NaSA + lidocaine group (NaSA 450 mg/kg + lidocaine 10 mg/kg, i.p., each day for 15 d). The expressions of GABA and Glu were examined with immunohistochemical method. The intensity-rate function, intensity-latency function and frequency-tuning curve were determined with extracellular electrophysiological recording. Results are as follows: (1) The expression of GABA in the NaSA and NaSA + lidocaine groups decreased remarkably compared with that in the control group; there was no noticeable difference between the NaSA and NaSA + lidocaine groups. The expression of Glu in the NaSA group increased significantly compared with that in the control and NaSA + lidocaine groups. No difference in the expression of Glu was found between the control and NaSA + lidocaine groups. (2) In NaSA group, the intensity-rate function displayed a non-monotonic pattern, rising at low intensity and descending at high intensity; the tip of frequency-tuning curves became broad after administration of NaSA. (3) The changes in intensity-rate function and intensity-latency function were not evident and the tips of the frequency-tuning curves sharpened in the NaSA + lidocaine group. These results suggest that administration of NaSA increases the expression of Glu-positive neurons and reduces that of GABA-positive neurons in the inferior colliculus. NaSA changes the auditory response properties of the inferior colliculus and lidocaine can reverse these changes.
